' 
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
8
Vitamin D treatment shows promise
Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.
Study highlights vitamin D efficacy
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
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7
Magnesium reduces brain injury markers
Effect of magnesium on functional outcome and paraclinical parameters of patients undergoing supratentorial craniotomy for brain tumors: a randomized controlled trial.
Moderate significance in findings
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
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9.5
Magnesium's role in brain tumor treatment
Posterior reversible encephalopathy syndrome in an oncological normotensive patient: evidence for a pathogenic role of concomitant low magnesium serum levels and chemotherapy treatment.
Medium relevance to treatment outcomes
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Read More
Most Useful Reviews
9.5
Effective treatment
I use this Arnica daily to strengthen my brain following injuries. Since 2017, I’ve taken 3 pellets twice a day. I am living proof that it works—despite numerous neurological injuries, my brain hasn’t re-injured after taking it. Last year, I fell and twisted my body but thankfully my brain remained intact. I am very grateful for this product, as previously I found nothing that helped with my condition.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9.5
Magnesium's role in brain tumor treatment
Posterior reversible encephalopathy syndrome in an oncological normotensive patient: evidence for a pathogenic role of concomitant low magnesium serum levels and chemotherapy treatment.
Medium relevance to treatment outcomes
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Read More
9
Calcium therapy improves glioblastoma treatment
Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogramming.
Limited isolation of calcium treatment
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
Read More
9
Calcium channels impact medulloblastoma
T-type calcium channels regulate medulloblastoma and can be targeted for therapy.
Calcium signaling pathways explored
We investigated the role of T-type calcium channels in medulloblastoma, a particularly aggressive brain tumor that primarily affects children. The study utilized various methodologies, including bulk and single-cell RNA sequencing, to assess T-type calcium channel expression.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Read More
9
Calcium affects brain tumor growth
Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth.
Supports calcium's complex role
We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
Read More
8
Vitamin D3 boosts glioblastoma treatment
Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform.
Potential treatment strategy explored
We developed an innovative method to tackle glioblastoma, a particularly aggressive brain tumor. Our approach involved creating a unique nanoplatform that combines vitamin D3, lipids, and neutrophil membranes to enhance the treatment's effectiveness.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Effective treatment
I use this Arnica daily to strengthen my brain following injuries. Since 2017, I’ve taken 3 pellets twice a day. I am living proof that it works—despite numerous neurological injuries, my brain hasn’t re-injured after taking it. Last year, I fell and twisted my body but thankfully my brain remained intact. I am very grateful for this product, as previously I found nothing that helped with my condition.
Read More
